Alright, so I like animation. Always have. I also like really offbeat and dry humor. Therefore, I was a big fan of Dr. Katz: Professional Therapist, a show that came on Comedy Central about 10-12 years ago. It was a show about a guy who was living with his grown son, who was not quite ready to take on life yet. He was a therapist to famous stand-up comics. Here are some clips:
Dr. Katz with Jon Stewart
Dr. Katz's Receptionist
Dr. Katz's son Ben is voiced by H. Jon Benjamin, who went on to voice Coach McGuirk in Home Movies, another wildly inventive and funny show. Dr. Katz's receptionist is voiced by Sarah Silverman's sister Laura Silverman.
The strange animation technique is called "Squigglevision", and it was invented by the guy who developed Dr. Katz into a show. It was later used in the Saturday morning show Science Court and Home Movies.